Which bodily system is primarily affected by Creutzfeldt-Jakob Disease (CJD)?

Creutzfeldt-Jakob Disease (CJD) primarily affects the central nervous system. This is a rare and progressive neurodegenerative disorder characterized by the accumulation of prion proteins in the brain. The presence of these abnormal proteins leads to brain damage, resulting in severe neurological symptoms such as rapid cognitive decline, personality changes, and movement disorders.

In the context of CJD, the central nervous system is the main site of pathology, as the disease disrupts normal brain function and can lead to encephalopathy. Understanding that CJD is fundamentally a neurological condition is crucial, as it differentiates it from diseases that affect other systems such as the digestive, respiratory, or endocrine systems, which are not directly involved in the pathophysiology of CJD.