Which enzyme is produced by Staphylococcus aureus that aids in its virulence?

Staphylococcus aureus produces coagulase, which is a key virulence factor that contributes to its pathogenicity. Coagulase is an enzyme that catalyzes the conversion of fibrinogen to fibrin, leading to the formation of clots. This clotting mechanism is important for S. aureus because it allows the bacteria to evade the host's immune system by forming a protective barrier around itself, essentially shielding it from phagocytosis by immune cells. Additionally, this ability to coagulate plasma can facilitate biofilm formation and help in persisting in host tissues during infection.

The production of coagulase is directly associated with the virulence of S. aureus, making it a significant factor in its ability to cause disease. Understanding this enzyme's role is crucial for comprehending how Staphylococcus aureus can lead to various infections, including skin and soft tissue infections, as well as more severe conditions like endocarditis and sepsis.